Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method (TSM) has emerged as a ground-breaking approach to reducing alcohol consumption through a medication-first strategy. By using Naltrexone to disrupt the brain’s reward cycle, it gradually helps people lose interest in alcohol.
The Sinclair Method, often referred to as TSM, has quietly revolutionised how we understand and treat Alcohol Use Disorder (AUD). Unlike traditional abstinence-only approaches, it offers a scientifically grounded, compassion-driven alternative. But where did it all begin?
At Rethink Drink, we're proud to be leading the charge in reshaping how the UK approaches alcohol recovery. For too long, individuals seeking change have faced limited choices: abstinence-only programmes, rigid systems, and shame-based narratives. We exist to offer a smarter, science-backed alternative — The Sinclair Method (TSM).
Traditionally, the path to recovery has been abstinence — quitting entirely, often with the support of meetings, rehab, or willpower alone. But what if you’re not ready to stop completely? What if your brain isn’t letting go that easily? Enter the Sinclair Method — a medically proven alternative that’s changing how we view and treat alcohol dependency.